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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMTC2 All Species: 16.36
Human Site: S263 Identified Species: 36
UniProt: Q8N394 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8N394 NP_689801.1 836 94130 S263 S D N P A A D S D S L L T R T
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086436 732 82592 W185 C A G C S M L W K E Q G V T V
Dog Lupus familis XP_539701 927 103389 S354 S D N P A A D S D S L L A R T
Cat Felis silvestris
Mouse Mus musculus Q56A06 836 94157 S263 S D N P A A D S D S L L A R T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512438 838 94326 S265 S D N P A A D S D S A L V R T
Chicken Gallus gallus XP_416123 896 100813 S323 S D N P A A D S D S F L T R M
Frog Xenopus laevis Q6DCD5 836 94386 C263 S D N P A A D C E V L L T R T
Zebra Danio Brachydanio rerio XP_682966 813 91406 L262 P A I N V W L L L C P D M L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQE9 849 93644 E272 A D N P T A H E S C F W T R T
Honey Bee Apis mellifera XP_392318 822 89253 M264 T L S F D W S M D A V P R I T
Nematode Worm Caenorhab. elegans Q20144 690 77719 D142 K Q L E H I F D F F N I A F S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 86.4 84.6 N.A. 95.6 N.A. N.A. 86.2 79.6 82.3 73.2 N.A. 36.5 41.9 20.8 N.A.
Protein Similarity: 100 N.A. 86.9 87.5 N.A. 97.8 N.A. N.A. 92 86.6 89.9 84.5 N.A. 54.6 57.4 38.1 N.A.
P-Site Identity: 100 N.A. 0 93.3 N.A. 93.3 N.A. N.A. 86.6 86.6 80 0 N.A. 46.6 13.3 0 N.A.
P-Site Similarity: 100 N.A. 6.6 93.3 N.A. 93.3 N.A. N.A. 86.6 86.6 86.6 6.6 N.A. 53.3 40 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 0 0 55 64 0 0 0 10 10 0 28 0 0 % A
% Cys: 10 0 0 10 0 0 0 10 0 19 0 0 0 0 0 % C
% Asp: 0 64 0 0 10 0 55 10 55 0 0 10 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 10 10 10 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 10 0 10 10 19 0 0 10 0 % F
% Gly: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 10 0 0 0 0 0 10 0 10 0 % I
% Lys: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % K
% Leu: 0 10 10 0 0 0 19 10 10 0 37 55 0 10 0 % L
% Met: 0 0 0 0 0 10 0 10 0 0 0 0 10 0 10 % M
% Asn: 0 0 64 10 0 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 10 0 0 64 0 0 0 0 0 0 10 10 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 10 64 0 % R
% Ser: 55 0 10 0 10 0 10 46 10 46 0 0 0 0 19 % S
% Thr: 10 0 0 0 10 0 0 0 0 0 0 0 37 10 64 % T
% Val: 0 0 0 0 10 0 0 0 0 10 10 0 19 0 10 % V
% Trp: 0 0 0 0 0 19 0 10 0 0 0 10 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _